Fibroblasts participated in mucosal pathology in the oral disease periodontitis

Abstract The oral cavity is a unique stricture; it combines mucosal and bone tissue microenvironments with their respective immunological responses. In fact, inflammation leads to destruction in the prevalent human disease, periodontitis. periodontitis, immune cells, particular Th17 neutrophil mediated responses have been linked pathogenesis, however not yet understood how stromal microenvironment may participate disease pathology. To date, studies humans reveal inflammatory signatures cells of recruitment. understand fibroblast function we performed scRNA-seq mouse mucosa during time course experimental periodontitis model. We characterize an early responding subpopulation distinct signature, characterized by induction IL33- ST2 cytokine axis. confirm soluble fibroblasts uncover immune-regulatory role for within microenvironment. Our work highlights nature immune-responsiveness provides insights into common disease. Supported NIH intramural funding